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The effect of applied paediatric burn blister ﬂuid and extracted exosomes from different depths on human dermal ﬁbroblasts and keratinocytes
Examensarbete på avancerad nivå, 2019 (MSc - Biotechnology)
Burn injuries are common types of wounds which have diﬀerent degrees of severity depending on the aﬀected tissue depth and size. The depths are classiﬁed as superﬁcial-partial thickness, deep-partial thickness or full thickness. During the burn wound healing process ﬂuid ﬁlled blisters can form in the skin, however the eﬀect of these are not fully understood...
Miniaturization of two high throughput metabolic stability assays in early drug discovery
Examensarbete på avancerad nivå, 2018 (MSc - Biotechnology)
When it was recognized that evaluation of pharmacokinetic (PK) properties during drug discovery strongly inﬂuenced the success rate during clinical development, ADME (Absorption, Distribution, Metabolism, Excretion) properties gained more and more attention in the pharmaceutical industry. One of the important PK properties to investigate is metabolic clearan...
Floderus Savonen, Lotta
Examensarbete på avancerad nivå, 2016 (MSc - Biotechnology)
Spider silk has shown potential for use as a biomaterial. If fused to antimicrobial peptides (AMPs), recombinant spider silk could be used for medical applications and reduce the need to use conventional antibiotics to battle infections. Recombinant spider silk 4RepCT was fused to the AMPs Magainin I, Lactoferricin and a synthetically derivedAMP referred to...
The Differential Rank Conservation Algorithm (DIRAC) Reveals Deregulation of Central Metabolic Pathways in Hepatocellular Carcinoma
Examensarbete på avancerad nivå, 2014 (MSc - Biotechnology)
Hepatocellular carcinoma (HCC) is a deadly disease without existing cure or effective treatment. If the genetics and metabolics of this form of liver cancer would be better understood the chance of developing effective treatments would likely increase.HCC cells are different from normal liver cells. When it comes to gene expression the traditional way is to...
Development and evaluation of Keratin 7/19 serum test for ovarian cancer in combination with biomarkers CA125 and HE4
Examensarbete på avancerad nivå, 2014 (MSc - Chemistry and biosciences)
Ovarian neoplasms are one of the most common pathologies among women of all age groups. It has been estimated that up to 10% of all women in the United States will undergo a surgical procedure owing to a suspected ovarian mass during their lifetime, and around a fifth of these women will suffer from malignancy. Early detection of ovarian cancer is crucial fo...