In English

Multi-sensor System for Non-invasive Online Liquid Analysis and Control in Bioreactors for Tissue and Organ Engineering

Vito Di Fonzo ; Shwan Ciyako
Göteborg : Chalmers tekniska högskola, 2013. 44 s. Technical report MC2 - Department of Microtechnology and Nanoscience, Chalmers University of Technology, ISSN 1652-0769, 2013.
[Examensarbete på avancerad nivå]

Having a controlled environment is a necessity for growing organs and tissues. To with- hold such controlled environment, monitoring devices are used to sense the quality of the perfusion medium. To ensure reproducibility of the experiments, a number of pa- rameters should be monitored and recorded. In this area of medicine, the experimental work requires multiple samples to be grown parallelly, in rather simple bio-reactors and utilization of today's macro scale sensor systems is unfeasible, both economically and practically. Emerging sensors based on micro technology are reducing the size of a multi- sensor systems, and making integration with electronics possible. Optical sensing allows minimally invasive measurements and long life-time. The aim of this thesis is to in- vestigate, design and develop such an integrated multi-sensor system capable of sensing several relevant parameters useful in this field, such as dissolved oxygen, pH, dissolved CO2, temperature, etc. A particular attention is also given to the complete system design in which the sensing devices are placed, in order to provide a comprehensive solution and a collection of best practices. Actuators, useful to maintain the required environmental conditions, will also be investigated and included. The system is meant to be functional in an experimental bioreactor designed and used by a research group in the area of regenerative medicine, sensing the parameters into the perfusion medium. This project was carried on in cooperation with Sahlgrenska University in Gothenburg, professor Suchitra Holgersson, and ACREO AB research institute, associate professor Cristina Rusu, and Chalmers University of Technology, professor Peter Enoksson.

Nyckelord: Biotechnology, Lab-on-Chip (LOC), SoC, Micro Total Analysis Systems (mTAS), Micro- measurement, Electronic tongue, Bioreactors, Organ engineering, Regenerative medicine, On-line analysis, Fluorescent sensor, pH, dO2, dCO2, High throughput system, Multi- parametric sensors, Metabolic assays, Oxygen consumption, Embedded, Cloud comput- ing, Internet-of-things, Raspberry Pi

Publikationen registrerades 2014-01-17. Den ändrades senast 2018-06-19

CPL ID: 192845

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